Protein name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) ;
Alternative:
Extracellular lysophospholipase D (LysoPLD) ;Autotaxin ;
Organism:
Bovine (Bos taurus).
General Annotation
Function:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Subcellular Location:
Secreted
Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Protein Attributes:
50:
MARRRSCQLH | QVISLFTFAV | GVNICLGVTA | NRIKRAEGWG | EGPPTVLSDS |
100:
PSINISGSCK | GRCFELQEAG | PPDCRCDNLC | KSYSSCCLDF | DELCLKTAGG |
150:
WECTKDRCGE | VRNEDHACHC | SEDCLARGDC | CTNYQVVCKG | ESHWVDDDCE |
200:
EIKTPECPAG | FVRPPLIIFS | VDGFRASYMK | KGSKVMPNIE | KLRSCGTHSP |
250:
YMRPVYPTKT | FPNLYTLATG | LYPESHGIVG | NSMYDPVFDA | HFNLRGREKF |
300:
NHRWWGGQPL | WITATKQGVI | AGTFFWPVVI | PHERRILTIL | QWLTLPDHER |
350:
PSVYAFYSEQ | PDFSGHKYGP | FGPEMTNPLR | DIDKTVGQLM | DGLKQLKLHR |
400:
CVNVIFVGDH | GMEDVTCDRT | EFLSNYLTNV | DDIILVPGTL | GRIRPKFNNH |
450:
AKYDPKVIIA | NLTCKKPDQH | FKPYLKQHLP | KRLHYANNRR | IEDVHLLVER |
500:
RWHVARKPLE | VYKKPSGKCF | FQGDHGFDNK | VNSMQTVFVG | YGPTFKYKTK |
550:
VPPFENIELY | NVMCDLLGLK | PAPNNGTHGS | LNHLLRTNTF | RPTVPEEVTR |
600:
PNYPGVMYLQ | SDFDLGCTCD | DKAEPKNKLD | ELNKHLHIKE | STEAETRKFR |
650:
GSKNEIKENV | NGNFEPRKER | HLLYGRPAVL | YRTRYDILYH | TDFESGYSEI |
700:
FLMPLWTSYT | VSKQADVSDI | PAHLTNCVRP | DVRVSPSFSQ | SCLAYKNDKQ |
750:
MSYGFLFPPY | LSSSPEAKYD | AFLVTNMVPM | YPAFKRIWNY | FQRVLVKKYA |
800:
SERNGVNVIS | GPIFDYDYDG | LHDTQDKIKQ | YVEGSSVPVP | THYYSILTSC |
850:
LDFTQPADRC | DGPLSVSAFV | LPHRPDNDES | CNSSEDESKW | VEELLKMHTA |
888:
RVRDIEHLTS | LDFFRKTSRS | YPEILTLKTY | LQTYESEI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Rat
ELISA Kit for Bovine E-NPP 2
ELISA Kit for Bovine E-NPP 2
ELISA Kit for Bovine E-NPP 2
ELISA Kit for Bovine E-NPP 2
CLIA Kit for Bovine E-NPP 2
CLIA Kit for Bovine E-NPP 2
CLIA Kit for Bovine E-NPP 2
CLIA Kit for Bovine E-NPP 2
Polyclonal Antibody for Bovine E-NPP 2
Polyclonal Antibody for Bovine E-NPP 2
Polyclonal Antibody for Bovine E-NPP 2
Polyclonal Antibody for Bovine E-NPP 2
Monoclonal Antibody for Bovine E-NPP 2
Monoclonal Antibody for Bovine E-NPP 2
Monoclonal Antibody for Bovine E-NPP 2
Monoclonal Antibody for Bovine E-NPP 2
Protein for Bovine E-NPP 2
Protein for Bovine E-NPP 2
Protein for Bovine E-NPP 2
Protein for Bovine E-NPP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Hippocampus .
2.
"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production."
Umezu-Goto M.
,
Kishi Y.
,
Taira A.
,
Hama K.
,
Dohmae N.
,
Takio K.
,
Yamori T.
,
Mills G.B.
,
Inoue K.
,
Aoki J.
,
Arai H.
J. Cell Biol.158:227-233(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 250-266; 749-777 AND 847-866
tissue :
Fetal blood .